Endocrine Abstracts

Protein ubiquitination modulates many physiological processes (e.g. cell proliferation). The ubiquitin-based signalling consists in both proteolytic and non-proteolytic functions: the first ones require modification of the target protein with polyubiquitination, a modification that induces the activation of the 26S-proteasome, whereas the second ones can be based on protein monoubiquitination. The recognition of ubiquitination diversity is dependent on specific Ub receptors th...

The sex hormone 17β-estradiol (E2) exerts its pleiotropic effects through the binding to the ligand-activated transcription factor estrogen receptor alpha (ERa). The E2:ERa complex regulates several physiological processes including cell survival and proliferation through transcriptional (i.e., estrogen responsive element (ERE)-based gene transcription) and non-transcriptional membrane-initiated effects (i.e., activation of signalling cascades).Many...